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急性非淋巴细胞白血病(ANLL)82例病人中,7例经化疗白血病细胞不减少而死于DIC。75例经化疗白血病细胞明显减少的6例在诱导缓解化疗期内死于DIC.9例伴发DIC,以后加大肝素剂量治疗。21例未加大肝素剂量治疗的18例伴发DIC。剩下39例未用肝素治疗的8例伴发DIC。总计有48例患者在15.2±6.3天伴发了DIC,其中30例白血病细胞的组织因子(TF)活性超过5.5L/10~(?)细胞,而仅有2例低于0.8L/10~(?)细胞,明显高于未伴发DIC者(0.3±4.2L/10~(?)细胞),P<0.01。所有M_3~-病人白血病细胞TF活性是7-230L/10~(?)细胞,平均38.9±2.3L/10~(?)细胞,明
Among 82 patients with acute non-lymphocytic leukemia (ANLL), 7 died of DIC after chemotherapy leukemia cells were not reduced. Of the 75 patients with chemotherapy-induced leukemia cells, 6 patients died of DIC.9 patients with DIC during the induction chemotherapy and later heparin dose. Eighteen patients with concomitant DIC who did not receive heparin dose were enrolled. The remaining 39 patients without heparin treatment of 8 cases with concomitant DIC. A total of 48 patients had DIC at 15.2 ± 6.3 days, of which 30 had leukemic cells with tissue factor (TF) activity exceeding 5.5 L / 10 ~ (?) Cells, while only 2 patients had a DIC lower than 0.8 L / 10 ~ (?) Cells were significantly higher than those without DIC (0.3 ± 4.2L / 10 ~ (?) Cells), P <0.01. The TF activity of leukemia cells from M 3 ~ - patients was 7-230 L / 10 ~ (?) Cells, with an average of 38.9 ± 2.3 L / 10 ~