目的研究舒必利片在健康人体内的药动学过程。方法 24名健康男性志愿者单剂量口服100mg舒必利片后,以HPLC测定血浆中舒必利浓度,用3P97软件计算。结果舒必利药-时曲线符合一室模型,线性范围15.625~1000μg·L-1,线性关系良好,最小可检测浓度为10μg·L-1。回收率为96.9~99.4%。药动学参数为T1/2为(9.84±1.85)h,Tmax为(3.56±0.86)h,Cmax为(264.0±89.41)ng·ml-1,AUC0~36为(3137.2±694.2)mg·h·ml-1,AUC0~∝为3935.8±579.5。结论方法简单,分析速度快,适用于血药浓度测定及药代动力学研究。 Objective To study the pharmacokinetics of sulpiride tablets in healthy volunteers. Methods Twenty-four healthy male volunteers were given 100 mg sulpiride tablets orally and the plasma concentration of sulpiride was measured by HPLC and calculated by 3P97 software. Results Sulpiride-time curve accorded with one-compartment model. The linear range was 15.625-1000 μg · L-1, the linearity was good, and the minimum detectable concentration was 10 μg · L-1. The recovery rate was 96.9 ~ 99.4%. The pharmacokinetic parameters were T1 / 2 (9.84 ± 1.85) h, Tmax (3.56 ± 0.86) h, Cmax of (264.0 ± 89.41) ng · ml-1 and AUC0-36 of (3137.2 ± 694.2) mg · h · Ml-1, AUC0 ~ α is 3935.8 ± 579.5. Conclusion The method is simple and fast in analysis. It is suitable for the determination of blood concentration and pharmacokinetics.