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为探讨一氧化氮（ＮＯ）、内皮素（ＥＴ）及５－羟色胺（５－ＨＴ）引发偏头痛的机制及其临床意义，对６８例偏头痛患者用分光光度法测定血浆ＮＯ、放射免疫法测定ＥＴ、荧光分光法测定５－ＨＴ含量。结果发现偏头痛发作期血浆ＮＯ、ＥＴ含量明显高于对照组（Ｐ＜０．０１），而５－ＨＴ含量明显低于对照组（Ｐ＜０．０１）；先兆期、间歇期血浆ＮＯ含量与对照组比较无差异；先兆期血浆ＥＴ含量与对照组比较差异有显著性意义（Ｐ＜０．０５），间歇期ＥＴ与对照组比较差异无显著性意义；先兆期、间歇期血浆５－ＨＴ含量明显高于发作期（Ｐ＜０．０１）。结果提示，５－ＨＴ是偏头痛发病的基础，是ＮＯ、ＥＴ的诱导剂和激活物；ＮＯ是引起血管扩张，导致偏头痛发作的主要因素；ＥＴ可能是导致血管收缩，引起先兆症状的重要因子。
To investigate the mechanism and clinical significance of migraine induced by nitric oxide (NO), endothelin (ET) and 5-hydroxytryptamine (5-HT), 68 patients with migraine were measured by spectrophotometry for plasma NO, radioimmunoassay Determination of ET, 5-HT content by fluorescence spectrophotometry. The results showed that the content of NO and ET in the migraine attack period was significantly higher than that in the control group (P <0.01), while the content of 5-HT was significantly lower than that in the control group (P <0.01) No significant difference compared with the control group; pre-ectrical plasma ET levels compared with the control group had significant difference (P <0.05), intermittent ET and the control group no significant difference; pre-and interictal plasma 5- HT content was significantly higher than the attack (P <0.01). The results suggest that 5-HT is the basis of migraine onset, NO, ET inducer and activator; NO is caused by vasodilation, leading to migraine attack the main factors; ET may lead to vasoconstriction, causing aura symptoms factor.