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目的探讨干扰素联合百令胶囊对慢性乙型肝炎进行抗病毒治疗的疗效观察。方法应用国产α干扰素(IFNα)治疗HBsAg,HBeAg,HBcAb均阳性的慢性乙型肝炎116例。治疗组58例用IFNα500万uim每周3次,百令胶囊1.0gpotid;对照组58例单用IFNα治疗。维生素等一般保肝药物两组相同,疗程均为6个月。结果治疗组HBeAg阴转率、HBeAb阳转率分别为75.86%,65.52%,对照组为51.72%,41.38%。两组比较差异显著(P<0.01或P<0.05)而HBsAg、HBcAb阴转率及HBsAb阳转率及肝功能复常,两组无差异(P<0.05)。结论IFNα联合百令胶囊疗法在抑制HBV复制和清除病毒方面比单用IFNα效果更佳,无明显不良反应。
Objective To investigate the efficacy of interferon combined with Bailing capsule in the treatment of chronic hepatitis B virus. Methods A total of 116 patients with chronic hepatitis B who were positive for HBsAg, HBeAg and HBcAb were treated with IFNα. Fifty-eight patients in the treatment group were treated with IFNα5 million uim three times a week and Bailing capsules 1.0gpotid. The control group, 58 cases, were treated with IFNα alone. Vitamins and other drugs in general the same two groups, treatment are 6 months. Results The HBeAg negative rate and HBeAb positive rate were 75.86% and 65.52% respectively in the treatment group and 51.72% and 41.38% in the control group. There were significant differences between the two groups (P <0.01 or P <0.05), while HBsAg and HBcAb negative conversion rate and HBsAb positive conversion rate and liver function were normal. There was no difference between the two groups (P <0.05). Conclusions IFNα combined with Bailing capsule treatment is better than IFNα in inhibiting HBV replication and virus removal without obvious adverse reactions.