论文部分内容阅读
目的比较 2型糖尿病胃轻瘫患者及健康志愿者血浆中的胃动素、胃泌素及内皮素水平及相关性。方法选择 2 0例 2型糖尿病胃轻瘫患者及 2 0例健康志愿者进行血浆标本观察 ,统一检测胃肠激素。结果 2型糖尿病胃轻瘫患者血浆中胃动素、胃泌素、内皮素水平 ,与疾病的病情程度具有相关性 ;2 0例糖尿病胃轻瘫患者中 ,胃动素 15例升高 ,2例降低 ,3例正常 ;胃泌素 15例升高 ,1例降低 ,4例正常 ;内皮素 16例升高 ,1例降低 ,3例正常。血清胃动素糖尿病组和健康对照组分别为 3 99.4± 12 2 .0和 2 76.3± 3 7.0 ,P<0 .0 1,有显著性差异 ;血清胃泌素糖尿病组和健康对照组分别为 5 7.1± 12 .2和 44 .3± 10 .1,P<0 .0 1,差异十分显著 (P<0 .0 1) ;血清内皮素糖尿病组和健康对照组分别为 71.4± 3 3 .7和 5 8.1± 16.5 ,P<0 .0 0 1,差异十分显著。结论 2型糖尿病胃轻瘫患者血浆中胃动素、胃泌素、内皮素水平 ,与疾病的病情程度具有相关性 ;胃动素、胃泌素、内皮素高于健康志愿者
Objective To compare the plasma levels of motilin, gastrin and endothelin in patients with type 2 diabetic gastroparesis and healthy volunteers. Methods 20 cases of type 2 diabetic patients with gastroparesis and 20 healthy volunteers were selected for plasma samples observation and gastrointestinal hormones were detected uniformly. Results The levels of plasma motilin, gastrin and endothelin in patients with type 2 diabetes mellitus with gastroparesis were correlated with the severity of the disease. In the 20 patients with diabetic gastroparesis, motilin was increased in 15 patients and 2 Cases decreased, 3 cases of normal; gastrin in 15 cases increased, 1 case decreased, 4 cases were normal; endothelin in 16 cases increased, 1 case decreased, 3 cases were normal. Serum motilin diabetic group and healthy control group were respectively 3 99.4 ± 12 2.0 and 2 76.3 ± 3 7.0, P <0.01, there was a significant difference; serum gastrin diabetic group and healthy control group were 5 7.1 ± 12.2 and 44.3 ± 10.1, P <0.01, the difference was significant (P <0.01). The serum endothelin level in diabetic group and healthy control group were 71.4 ± 33, respectively. 7 and 5 8.1 ± 16.5, P <0.001, the difference is very significant. Conclusions The levels of plasma motilin, gastrin and endothelin in type 2 diabetic patients with gastroparesis are correlated with the severity of the disease. Motilin, gastrin and endothelin are higher than those in healthy volunteers