近年来 ,许多研究表明 ,人类肿瘤及其细胞系中广泛存在染色体 9ｐ2 1～ 2 2区域的异常 ,如纯合性缺失、杂合性丢失、易位、倒位等。因此认为此区存在着抑癌基因。最初发现 ｐ1 6基因定位于染色体 9ｐ2 1 ,与许多恶性肿瘤有关 ,但并非此区惟一抑癌基因 ,进一步发现该区域的 ｐ1 In recent years, many studies have shown that there are widespread abnormalities in 9p21 ~ 22 of chromosomes in human tumors and their cell lines, such as homozygous deletion, loss of heterozygosity, translocation, inversion and the like. So think there is tumor suppressor gene in this area. Initially found p1 6 gene located on chromosome 9p2 1, and many malignant tumors, but not the only tumor suppressor gene, and further found that the region p1