目的:评价粒细胞刺激因子(G-CSF)治疗急性骨髓性白血病(AML)的疗效。方法:计算机检索PubMed、EM-Base、Cochrane图书馆、CBM、CNKI数据库,手检其他白血病相关杂志,对纳入的随机对照试验(RCT)进行方法学质量评价,并用RevMan5.0软件进行Meta分析。结果:共纳入11个RCT,A、B、C级文章分别有3,5,3篇。合并分析结果显示完全缓解率(CR)、总有效率(OS)、复发、感染等组间差异均显著性。结论:基于目前临床研究结果G-CSF不能增加患者完全缓解率、总有效率,亦不能降低复发、感染。 Objective: To evaluate the efficacy of granulocyte-stimulating factor (G-CSF) in the treatment of acute myeloid leukemia (AML). METHODS: PubMed, EM-Base, Cochrane Library, CBM and CNKI databases were searched by computer and other leukemic related hand-searched journals. The methodological quality of randomized controlled trials (RCTs) was evaluated and Meta-analysis was performed by RevMan 5.0 software. Results: A total of 11 RCTs were included, and 3, 5, 3 articles were available for A, B and C articles respectively. The combined analysis showed that the CR, OS, recurrence and infection were significantly different among the groups. Conclusion: Based on the results of current clinical research, G-CSF can not increase the complete remission rate and the total effective rate of patients, nor can it reduce the recurrence and infection.