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本文研究了机体摄入不同水平的浓缩铀（２３５）~ＵＯ_２Ｆ_２时，引起外周免疫器官脾淋巴细胞ＤＮＡ合成和ＵＶ诱发的ＵＤＳ变化。观察发现，当机体摄入低剂量浓缩轴（２３５）~ＵＯ_２Ｆ_２０．１μｇ／ｋｇ体重时，ＰＨＡ反应性Ｔ淋巴细胞的３Ｈ－ＴｄＲ掺入量显著增升，呈现对ＤＮＡ合成的明显兴奋效应。而当浓缩铀（２３５）~ＵＯ_２Ｆ_２的摄入水平在０．０１～２０μｇ／ｋｇ体重时；可使ＵＶ诱发的脾淋巴细胞ＵＤＳ呈现兴奋效应，对脾淋巴细胞ＤＮＡ切除修复能力明显增强。而当浓缩铀（２３５）~ＵＯ_２Ｆ_２的内污染水平进一步加大时，可使脾Ｔ、Ｂ淋巴细胞的ＤＮＡ合成和ＵＤＳ都呈现出抑制效应。
In this paper, we investigated the changes of UDS induced by DNA synthesis and UV-induced splenic lymphocytes in peripheral immune organs when ingested with different levels of uranium (235) ~ UO 2 F 2. The results showed that the incorporation of 3H-TdR into PHA-reactive T lymphocytes increased significantly when the body was exposed to a low dose of (235) ~ UO_2F_ (20.1μg / kg body weight), showing obvious excitatory effect on DNA synthesis. When uranium (235) ~ UO_2F 2 was in the range of 0.01 ~ 20μg / kg body weight, UV-induced splenic lymphocyte UDS showed an excitement effect, and the spleen lymphocyte DNA excision and repair ability was significantly enhanced. When the level of contamination of uranium (235) ~ UO_2F_2 was further increased, the DNA synthesis and UDS of T and B lymphocytes in spleen were inhibited.