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铜蓝蛋白是分布在α_2-球蛋白区域的铜结合糖蛋白。血清铜的95％是铜蓝蛋白结合铜,其余5％是清蛋白结合铜。铜蓝蛋白具有氧化酶的活力,故亦称铜氧化酶。其生物学功能是运输铜和参加铁的代谢,在血清中亦是最主要的抗氧化剂,能预防有害的多烯酸和其它基质的氧化,清除过氧化物。铜蓝蛋白在急、慢性炎症、恶性肿瘤、贫血、胆道等疾病中,均会发生明显的改变。因此,近年来不少人在这方面作了探讨。在动物方面,测定铜蓝蛋白含量尚未见有报导。本人在1983年的实验研究中,测定了昆明种小鼠血清铜蓝蛋白的含量,并发现鼠龄不同血清铜蓝蛋白含量有明显差异,现将实验情况报导如下:
Ceruloplasmin is a copper-binding glycoprotein that is distributed in the α_2-globulin region. 95% of serum copper is ceruloplasmin-bound copper and the remaining 5% is albumin-bound copper. Ceruloplasmin has the activity of oxidase, it is also known as copper oxidase. Its biological function is to transport copper and participate in the metabolism of iron, also in serum is the most important antioxidant, can prevent the harmful oxidation of polyunsaturated acid and other substrates, remove peroxide. Ceruloplasmin in the acute and chronic inflammation, cancer, anemia, biliary and other diseases, there will be significant changes. Therefore, in recent years, many people have discussed this issue. In animals, the determination of ceruloplasmin content has not been reported. In my 1983 experimental study, the determination of Kunming mice serum ceruloplasmin content, and found that different age mice serum ceruloplasmin content were significantly different, the experimental report is as follows: