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目的研究肝硬变（ＬＣ）患者联合检测血清人Ⅲ型前胶原（ＨＰＣⅢ），Ⅳ型胶原（ＣⅣ），透明质酸（ＨＡ）和层粘蛋白（ＬＮ）的意义．方法ＬＣ患者６４例，男４０例，女２４例，平均年龄４５岁±２３岁；其中乙型肝炎性肝硬变５７例，丙型肝炎性肝硬变２例，酒精性肝硬变４例，心源性肝硬变１例；伴消化道出血２例，腹水３６例，肝性脑病１２例和肝肾综合征４例．ＣｈｉｌｄＡ级２８例，Ｂ级２３例，Ｃ级１３例．采用ＲＩＡ法分别检测空腹血清ＨＰＣⅢ，ＣⅣ，ＨＡ及ＬＮ水平，并与４０例（男２６例，女１４例，平均年龄４２±２０岁）健康人作对照．结果肝硬变患者血清ＨＰＣⅢ，ＣⅣ，ＨＡ及ＬＮ水平（μｇ／Ｌ）Ａ级（３２３４±１０１２，２９８６±９８３，５６４６±１５２３，２２６４±４５６）明显高于健康对照组（８２３±１５４，５２７±１７２，４８２±２６３，１０９３±１６２）和肝硬变Ｂ级（２１６２±６４３，１２１５±６２６，２８７６±１７２５，１８６９±２７７）及Ｃ级（２２１５±６８７，１３２４±６８７，２９０４±１６８６，１８９６±４０５）（Ｐ＜００１），肝硬变Ｂ，Ｃ级患者间无显著性差异?
Objective To study the significance of combined detection of serum human type Ⅲ procollagen (CⅣ), hyaluronic acid (HA) and laminin (LN) in patients with cirrhosis (LC). Methods LC patients 64 cases, 40 males and 24 females, mean age 45 years ± 23 years; 57 cases of hepatitis B cirrhosis, hepatitis C cirrhosis in 2 cases, alcoholic cirrhosis in 4 cases , 1 case of cardiogenic cirrhosis; 2 cases of gastrointestinal bleeding, ascites in 36 cases, hepatic encephalopathy in 12 cases and hepatorenal syndrome in 4 cases. ChildA grade 28 cases, B grade 23 cases, C grade 13 cases. The levels of fasting serum HPCⅢ, CIV, HA and LN were detected by RIA method and compared with 40 healthy people (26 males and 14 females, mean age 42 ± 20 years old). Results Serum levels of HPCⅢ, CⅣ, HA and LN in cirrhotic patients were grade A (3234 ± 1012,2986 ± 983,5646 ± 1523,2264 ± 456) were significantly higher than those in healthy control group (823 ± 154, 527 ± 172, 482 ± 263, 1093 ± 162) and cirrhosis grade B 216.2 ± 64.3, 121.5 ± 62.6, 187.6 ± 172.5, 186.9 ± 27.7) and C (221.5 ± 68.7, 132.4 ± 68 7,2904 ± 1686,1896 ± 405) (P <001), cirrhosis B, C grade patients no significant difference?