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目的探讨非高密度脂蛋白胆固醇(non-HDL-C)与老年急性冠状动脉综合征(ACS)病程的相关性。方法选取85例老年健康体检者为对照组,125例老年急性冠状动脉综合征患者(ACS组)为研究对象,ACS组包括74例老年不稳定型心绞痛(UA)患者和51例老年急性心肌梗死(AMI)患者,采用免疫比浊法检测血清中三酰甘油(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(apo A-Ⅰ)和载脂蛋白B(apo B)浓度,并按弗洛斯特(Frost)公式计算non-HDL-C浓度。结果 ACS组和健康对照组比较,血清TG、TC、HDL-C、LDL-C、apo A-1和non-HDL-C差异均有统计学意义(P<0.05);与UA组相比,AMI组血清non-HDL-C显著性升高(P<0.05)。Logistic回归分析发现non-HDL-C在老年ACS中的危险因素最高(OR=7.684),相关性分析发现non-HDL-C与ACS进程的相关性最好(r=0.674)。结论与传统的血脂项目相比,non-HDL-C更有利于监测老年ACS发病风险并与其病程相关。
Objective To investigate the relationship between non-HDL-C and the course of senile acute coronary syndrome (ACS). Methods Eighty-five elderly healthy subjects were selected as control group and 125 elderly patients with acute coronary syndrome (ACS group) were enrolled. The ACS group consisted of 74 elderly patients with unstable angina pectoris (UA) and 51 elderly patients with acute myocardial infarction (AMI). Serum triglyceride (TG), cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A (apo A-Ⅰ) and apolipoprotein B (apo B) concentrations were calculated and the concentration of non-HDL-C was calculated according to the Frost formula. Results Compared with healthy control group, there were significant differences in TG, TC, HDL-C, LDL-C, apo A-1 and non-HDL-C between ACS group and healthy control group Serum non-HDL-C in AMI group was significantly higher (P <0.05). Logistic regression analysis showed that the risk of non-HDL-C was the highest in elderly ACS (OR = 7.684). Correlation analysis showed that the correlation between non-HDL-C and ACS progression was the highest (r = 0.674). Conclusion Compared with the traditional blood lipid project, non-HDL-C is more conducive to monitoring the risk of elderly ACS and its duration.