感染继发性细粒棘球蚴的小鼠口服阿苯达唑亚砜150mg/kg·d×28d 时,细粒棘球蚴囊的生发层超微结构的变化主要是皮层受损、皮层细胞核周胞质广泛溶解和空泡形成、线粒体肿大和变性等,与阿苯达唑相仿。感染小鼠口服吡喹酮500mg/kg·d,连给3个月时,生发层超微结构的变化与给药15～30d 的相仿。动物剖检时仅少数囊塌陷和干瘪。这些囊的超微结构于停药6个月后仍示有严重损害。 In mice infected with Echinococcus granulosus albendazole sulfamethoxazole 150mg / kg · d × 28d, the ultrastructure of the germinal layer of Echinococcus granulosus mainly changes in cortical damage, cortical nucleus Cytoplasm widely dissolved weeks and the formation of vacuoles, mitochondria swelling and degeneration, and albendazole similar. In mice infected with oral praziquantel 500mg / kg · d, even to 3 months, the germinal layer ultrastructure changes and administration 15 ~ 30d similar. Only a few sacs collapsed and shriveled during animal autopsy. The ultrastructure of these bladders still showed severe damage 6 months after discontinuation.