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目的 :定量检测湖南SLE患者的sHLA -Ⅰ类分子水平。方法 :采用ELISA双抗夹心法检测血浆的sHLA -Ⅰ类分子水平。结果 :血浆sHLA -Ⅰ类分子水平 :2 6例活动期SLE患者为 970 .46± 34 2 .79μg/L ,2 9例非活动期SLE患者为 719.93± 10 2 .2 4μg/L ,37例正常人为 5 5 8.18± 189.6 9μg/L ,与正常人相比SLE活动期 (P <0 .0 1)和非活动期 (P <0 .0 5 )均明显增高 ,且活动期明显高于非活动期 (P <0 .0 1)。结论 :活动期和非活动期SLE患者血浆的sHLA -Ⅰ类分子水平明显增高 ,且活动期增高更显著
Objective: To quantitatively detect the level of sHLA-Ⅰ in Hunan SLE patients. Methods: Plasma levels of sHLA-Ⅰ were detected by ELISA double-antibody sandwich method. Results: Plasma levels of sHLA-Ⅰin the plasma were 970.46 ± 34.279μg / L in 26 active SLE patients, 719.93 ± 102.24μg / L in 29 inactive SLE patients and 37 The normal control group was 51.88 ± 189.6 9μg / L, the activity of SLE (P <0.01) and inactive period (P <0.05) were significantly higher than that of normal subjects, and the activity was significantly higher than that of non-active Active period (P <0 .01). CONCLUSIONS: The level of sHLA-I molecules in the plasma of active and inactive SLE patients was significantly increased, and the activity increased more significantly