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目的分析甲巯咪唑引发抗中性粒细胞胞质抗体相关性小血管炎的案例,为临床防治提供参考。方法患者因甲状腺功能亢进规律服用甲巯咪唑10mg,bid 1年余,因呼吸系统症状入院治疗,入院后发现该患者有咯血、血尿、肾功能不全等表现,分析该表现与用药的相关性。结果该临床表现很可能为甲巯咪唑引发的抗中性粒细胞胞质抗体相关性小血管炎。结论甲巯咪唑在治疗甲状腺功能亢进过程中可引发抗中性粒细胞胞质抗体相关性小血管炎。早期诊断和合理治疗是减少不良反应的关键。
Objective To analyze the case of methimazole-induced anti-neutrophil cytoplasmic antibody-associated vasculitis and provide reference for clinical prevention and treatment. Methods Patients were treated with methimazole 10 mg bid for more than one year due to hyperthyroidism. The patients were admitted to hospital due to respiratory symptoms. The patients were found to have hemoptysis, hematuria and renal insufficiency after admission. The correlation between the performance and medication was analyzed. Results The clinical manifestations were most likely to be methimazole-induced anti-neutrophil cytoplasmic antibody-associated vasculitis. Conclusion Methimazole can induce anti-neutrophil cytoplasmic antibody-associated vasculitis in the treatment of hyperthyroidism. Early diagnosis and reasonable treatment is the key to reduce adverse reactions.