【摘 要】
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Galectin-3 (Gal-3) in oligodendrocyte (OLG) differentiation:OLGs are the cells in charge of myelination in the central nervous system (CNS),allowing rapid condu
【机 构】
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Department of Biological Chemistry, School of Pharmacy and Biochemistry, Institute of Chemistry Biol
论文部分内容阅读
Galectin-3 (Gal-3) in oligodendrocyte (OLG) differentiation:OLGs are the cells in charge of myelination in the central nervous system (CNS),allowing rapid conduction of the neural action potential and giving trophic support to axons.OLGs undergo a series of changes throughout their life cycle:first,upon neural stem cell commitment to the OLG lineage,cells referred to as OLG precursor cells (OPC) present a bipolar morphology,have proliferative and migratory capacity and express molecular markers like platelet-derived growth factor receptor alpha and neural/glial antigen 2;next,in an intermediate stage called preOLG,OLGs are more ramified and express CNPase,Olig1 and O4,among others;finally,cells develop into myelin forming cells which express molecular markers like myelin basic protein (MBP),adenomatous polyposis polyposis and proteolipid protein (Franklin et al.,2017).
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