In this paper,a new method combines chemical/physical crosslinking,and emulsification-foaming porogenic was adopted to prepare n-hydroxyapatite (n-HA)/polyvinyl alcohol (PVA)/chitosan (CS) porous composite hydrogel using artificial cea scaffold materials.The fabricate conditions,including the type and amount of emulsification-foaming porogen,mixing time and speed etc.were researched.The results showed the optimal condition that the alkylphenol polyoxyethylene ether (OP) acted as emulsification-foaming porogen,with the ratio of WPVA/Wop as 3.75,and mixing 15 min with a stirring speed of 800 r· min-1.Additionally,the fabricated composite hydrogel scaffold materials possessed interconnected intal holes,a moisture content of above 65％,and tensile strength of above 6 MPa.In vitro cytotoxicity and acute systemic toxicity assay confirmed that the scaffolds did not show any cytotoxicity.The as-prepared hydrogel could be a promising candidate for artificial cea scaffold material.