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目的:观察低分子肝素钙治疗早发型重度子痫前期对母体的影响。方法:选取孕龄26～34周重度子痫前期患者60例,随机分为观察组和对照组,观察组在常规治疗基础上加用低分子肝素钙,对比两组血压、血脂、24 h尿蛋白定量、凝血纤溶功能、并发症的差异。结果:观察组平均动脉压、24 h尿蛋白、血脂TG、TC、LDL、apo-B均下降,HDL、apo-A增加,两组间差异有统计学意义(P<0.05);凝血功能无改变,纤溶活性降低,产后出血无增加,并发症降低。结论:抗凝治疗早发型重度子痫前期是有效安全的,低分子肝素钙可作为基本治疗药物之一。
Objective: To observe the influence of low molecular weight heparin on maternal premature preeclampsia. Methods: Sixty patients with severe preeclampsia aged 26-34 weeks were randomly divided into observation group and control group. The observation group was given low molecular weight heparin calcium on the basis of routine treatment. The blood pressure, blood lipid, 24 h urine Protein quantification, coagulation and fibrinolysis, complications. Results: The mean arterial pressure, the content of 24 h urinary protein, TG, TC, LDL and apo-B in the observation group decreased and the levels of HDL and apo-A increased in the observation group, with statistical significance (P <0.05) Changes, reduced fibrinolytic activity, no increase in postpartum hemorrhage, complications decreased. Conclusion: Anticoagulant therapy for early-onset severe preeclampsia is effective and safe, and low-molecular-weight heparin calcium can be used as one of the basic treatment drugs.