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为了证实雷公藤多甙(GTW)是否对家兔急性实验性血清病(AESS)有治疗作用,我们以家兔AESS为实验模型,设对照组和治疗组,每组动物各17只。治疗组于注射牛血清白蛋白(BSA)前2天和注射后给GTW15mg/kg/d胃管灌服,临用前将GTW混悬于0.5％羧甲基纤维素钠(CMC),共2周。对照组胃管灌服等量0.5％CMC,共2周。结果证明:治疗组与对照组动物相比,循环中特异性BSA-抗BSA复合物和血清中抗BSA-IgG抗体显著减少,血清中总补体量增高,肾组织炎性病变和肾小球内免疫复合物沉积减轻,血浆白蛋白、肌酐均恢复正常,充分说明GTW对家兔AESS确实有治疗作用;并对其作用机理作了讨论。
In order to confirm whether GTW has a therapeutic effect on acute experimental sera from rabbits (AESS), we set up the AESS model in rabbits and set up control group and treatment group, 17 animals in each group. The treatment group was given GTW15mg / kg / d gastric tube 2 days before injection of bovine serum albumin (BSA) and GTW was suspended in 0.5% sodium carboxymethylcellulose (CMC) before use week. The control group, gastric perfusion with the same amount of 0.5% CMC, a total of 2 weeks. The results showed that compared with the control group, the specific BSA-anti-BSA complex in the treatment group and the anti-BSA-IgG antibody in the serum were significantly decreased, the total amount of complement in the serum was increased, the inflammatory lesions in the kidney and glomerular Immune complex deposition reduced, serum albumin, creatinine were back to normal, fully demonstrated GTW rabbit AESS does have a therapeutic effect; and its mechanism of action are discussed.