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检测３０例正常对照、２５例良性肺疾病、５５例非小细胞肺癌（ＮＳＣＬＣ）和１５例小细胞肺癌（ＳＣＬＣ）患者血清神经元特异性烯醇酶（ＮＳＥ）和胃泌素及其在治疗前后的动态变化，结果显示，血清ＮＳＥ和胃泌素在４组间差异有极显著性（Ｐ＜０００１），ＮＳＥ均值分别为８２２、１０８４、１４６４和３２００μｇ／Ｌ，胃泌素均值分别为５９４７、８２００、２２１５３和３５６８６ｎｇ／Ｌ。以２０３μｇ／Ｌ（ＮＳＥ）和８１４ｎｇ／Ｌ（胃泌素）为正常参考值上限，ＮＳＥ阳性率分别是８０％（ＳＣＬＣ）和１４５４％（ＮＳＣＬＣ），胃泌素分别是８０％（ＳＣＬＣ）和６３６３％（ＮＳＣＬＣ）。肺癌治疗后血清ＮＳＥ和胃泌素在ＳＣＬＣ组均显著下降（Ｐ＜０００１），而ＮＳＣＬＣ组仅有胃泌素降低（Ｐ＜０００１）。因此，ＮＳＥ主要用于ＳＣＬＣ的诊断、组织学分型及疗效监测，而胃泌素可以用于各型肺癌，两者联合可以提高临床应用价值。
Detection of serum neuron specific enolase (NSE) and gastrin in 30 normal controls, 25 benign lung diseases, 55 non-small cell lung cancer (NSCLC) and 15 small cell lung cancer (SCLC) patients and their treatment Before and after the dynamic changes, the results showed that the serum NSE and gastrin were significantly different between the four groups (P <0 001), the average NSE was 8 22, 10 84, 14 64 and 32 00 g g /L, mean values of gastrin were 59 47, 82 00, 221 53, and 356 86 ng/L, respectively. The upper limit of normal reference was 203μg/L (NSE) and 814ng/L (gastrin). The positive rate of NSE was 80% (SCLC) and 1454% (NSCLC) respectively. Gastrin was 80% (SCLC) and 6363% (NSCLC). After treatment of lung cancer, serum NSE and gastrin in SCLC group were significantly decreased (P <0 001), while NSCLC group only gastrin decreased (P <0 001). Therefore, NSE is mainly used for the diagnosis of SCLC, histological type and efficacy monitoring, and gastrin can be used for various types of lung cancer, and the combination of the two can improve the clinical application value.