目的:对河北省农村孕妇妊娠结局进行前瞻性流行病学调查,以了解自然流产、引产、死产、早产、新生儿死亡、先天性畸形儿等不良妊娠结局的发生率及其危险因素。方法:随机抽取全省11个市50个县中的191个乡镇为调查单位,对调查单位2002年7月1日~2003年12月31日早期妊娠的妇女进行跟踪随访,随访时间自妊娠早期至婴儿出生满1周岁。结果:随访孕妇总例数为24052,自然流产率3.5%、引产率1.5%、死产率为0.64%、早产率4.2%;新生儿死亡率6‰,孕妇死亡率0.1‰;该次调查发现56种共226例畸形儿,其中单发畸形32种(172例);多发畸形24种(54例),畸形儿总发生率为94.0/万;不良妊娠结局总发生率为6.4%,与年龄、既往不良孕产史、家族病史等有关,并有明显的地区差别。结论:研究结果表明了河北省农村孕妇妊娠结局状况及其相关因素,为今后在河北省开展优生优育工作和制定出生缺陷干预措施提供了依据。 Objective: To investigate the pregnancy outcome of pregnant women in rural areas of Hebei Province, a prospective epidemiological investigation to understand the incidence of spontaneous abortion, induced labor, stillbirth, premature birth, neonatal death, congenital malformations and other adverse pregnancy outcomes and risk factors. Methods: Totally 191 villages and towns in 50 counties in 11 cities of the province were randomly selected as the investigation units. The follow-up and follow-up of women from early July, 2002 to December 31, 2003 in the investigation unit was conducted from the first trimester of pregnancy To the baby was born one year old. Results: The total number of follow-up pregnant women was 24052, the spontaneous abortion rate was 3.5%, the rate of induced abortion was 1.5%, the rate of stillbirth was 0.64% and the rate of premature birth was 4.2%. The neonatal mortality rate was 6 ‰ and the maternal mortality rate was 0.1 ‰. 56 kinds of 226 cases of deformed children, including 32 cases of single malformations (172 cases); 24 cases of multiple malformations (54 cases), the total incidence of deformed children was 94.0 / million; the overall incidence of adverse pregnancy outcomes was 6.4% , Past history of poor maternal history, family history and other related, and there are obvious regional differences. Conclusion: The results of the study show that pregnant women in rural areas of Hebei pregnancy outcome and related factors for the future in Hebei Province to carry out prenatal and postnatal care work and to provide birth defects intervention provides the basis.