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应用紫外分光光度法观察西米替丁及法莫替丁对胃乙醇脱氢酶的影响。结果表明：当西米替丁浓度为０．０１ｍｍｏｌ／Ｌ时，乙醇脱氢酶活性已明显下降，抑制率达４４．９％（Ｐ＜０．０１），药物浓度越高，抑制作用越强，当西米替丁浓度达２０ｍｍｏｌ／Ｌ时，酶活性下降８３．３％。而法莫替丁浓度达１ｍｍｏｌ／Ｌ时才出现轻度的抑制作用。因此，对饮酒患者需要应用Ｈ２受体拮抗剂治疗宜选择法莫替丁
The effect of cimetidine and famotidine on gastric alcohol dehydrogenase was observed by ultraviolet spectrophotometry. The results showed that when the concentration of cimetidine was 0.01 mmol / L, the activity of alcohol dehydrogenase was significantly decreased, with the inhibition rate reaching 44.9% (P <0.01). The higher the drug concentration, the stronger the inhibition When the concentration of cimetidine reached 20mmol / L, the enzyme activity decreased by 83.3%. The concentration of famotidine up to 1mmol / L only mild inhibition. Therefore, the need for alcohol consumption in patients with H2 receptor antagonist therapy should choose famotidine