目的观察降钙素联合阿仑膦酸盐治疗原发性骨质疏松症的临床效果。方法 63例女性原发性骨质疏松症患者随机分为两组,对照组(31例),试验组(32例,加用降钙素),63例患者治疗6个月。治疗前后化验检查患者血钙、血磷水平、经EXPERT-XL型双能X线骨密度仪测定骨密度,并根据患者主诉进行疼痛评价。比较两组患者治疗前后的疗效差别。结果经6个月治疗后,治疗组患者骨密度较对照组提高,腰腿痛缓解率较对照组增加。结论降钙素联合阿仑膦酸盐能更有效的治疗原发性骨质疏松,增加腰腿痛缓解率,是一种很理想的药物联合治疗方法。 Objective To observe the clinical effect of calcitonin combined with alendronate in the treatment of primary osteoporosis. Methods Sixty-three women with primary osteoporosis were randomly divided into two groups: control group (31 cases), experimental group (32 cases, plus calcitonin) and 63 patients for 6 months. The levels of serum calcium and phosphorus in the patients before and after the treatment were measured by the method of EXPERT-XL dual energy X-ray absorptiometry. The pain was evaluated according to the patients’ complaints. The difference between the two groups before and after treatment was compared. Results After 6 months of treatment, the BMD of the treatment group was higher than that of the control group, and the relief rate of low back pain was higher than that of the control group. Conclusion Calcitonin combined with alendronate can be a more effective treatment of primary osteoporosis, increase the rate of low back pain relief, is a very good combination of drugs.