胆囊收缩素(CCK)是一种脑肠肽,它在哺乳动物中枢神经系统的含量比任何一种已知的其它调节性激素的含量都高。我们曾发现P_(77)PMC癫痫大鼠脑中CCK含量比正常大鼠低。CCK的降低可能是由于该基因缺失或重排等异常改变造成的;也可能是该基因表达调控失常造成的。为此,我们利用从国外引进的,克隆有CCK cDNA的质粒pCCK作探针,应用Sou- Cholecystokinin (CCK) is a ghrelin that is present in the central nervous system of mammals at a higher concentration than any of the other known regulatory hormones. We have found that P_ (77) PMC epilepsy rat brain CCK levels lower than normal rats. The decrease of CCK may be caused by abnormal changes such as deletion or rearrangement of the gene or the abnormal regulation of the gene expression. To this end, we use the introduction of a foreign CCK cDNA cloning plasmid pCCK probe, the use of Sou-