论文部分内容阅读
目的探讨氯吡格雷联合拜阿司匹林治疗急性脑梗死的疗效。方法本研究选取急性脑梗死患者100例,按照数字随机方式将全部患者分为对照组和实验组,各50例,两组患者分别采用拜阿司匹林治疗、氯吡格雷联合拜阿司匹林治疗,对两组患者的临床疗效进行观察比较。结果对照组患者、实验组患者的临床治疗总有效率分别为78.0%、96.0%,两者比较差异有统计学意义(P<0.05);治疗前两组患者的神经功能缺损评分比较差异无统计学意义,治疗后两组患者的神经功能缺损评分均显著优于治疗前(P<0.05),而且实验组患者治疗后的神经功能缺损评分显著优于对照组(P<0.05);实验组患者治疗后的hs-CRP水平、IL-6水平、IL-8水平均显著低于对照组(P<0.05)。结论在对急性脑梗死患者进行治疗时,氯吡格雷联合拜阿司匹林治疗具有比较显著的临床效果,能对患者临床症状进行显著改善,具有临床应用价值。
Objective To investigate the efficacy of clopidogrel combined with aspirin in the treatment of acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction were enrolled in this study. All patients were divided into control group and experimental group according to random number. All patients were treated with aspirin and clopidogrel combined with aspirin. The clinical efficacy of patients were observed and compared. Results The total effective rate of clinical treatment in control group and experimental group was 78.0% and 96.0% respectively, there was significant difference between the two groups (P <0.05). There was no significant difference in the scores of neurological deficits between the two groups before treatment (P0.05), and the scores of neurological deficits in the experimental group were significantly better than those in the control group (P0.05). In the experimental group, the neurological deficit scores of the two groups were significantly better than those before treatment The levels of hs-CRP, IL-6 and IL-8 in the treated group were significantly lower than those in the control group (P <0.05). Conclusion Clopidogrel combined with aspirin has a significant clinical effect in the treatment of patients with acute cerebral infarction, and can significantly improve the clinical symptoms of patients with clinical application value.