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目的:探讨盐酸帕罗西汀对脑卒中后束缚应激大鼠脑内单胺递质的影响。方法:建立脑卒中后束缚应激大鼠模型,观察各组大鼠糖水消耗试验、自发性行为改变和下丘脑单胺类神经递质的变化。结果:模型组大鼠蔗糖水饮用量、旷野实验水平及垂直得分、下丘脑NE、5-HT、DA含量等与正常组相比明显减少;帕罗西汀组大鼠糖水饮用量、旷野实验中的得分和下丘脑神经递质的含量较模型组大鼠明显增加。结论:盐酸帕罗西汀对脑卒中后束缚应激大鼠模型的作用可能与增加下丘脑单胺类神经递质的含量有关。
Objective: To investigate the effect of paroxetine hydrochloride on monoamine neurotransmitters in the brain of rats with restraint stress after stroke. Methods: The rat model of post-stroke restraint stress was established. The consumption of sugar and water, the changes of spontaneous behavior and the changes of monoamine neurotransmitter in the hypothalamus of rats in each group were observed. Results: The sucrose water consumption, wilderness experimental level and vertical score, hypothalamic NE, 5-HT and DA content in the model group were significantly decreased compared with those in the normal group. In the paroxetine group, Scores and hypothalamic neurotransmitters than the model group rats increased significantly. CONCLUSION: Paroxetine hydrochloride may play a role in increasing the content of monoamine neurotransmitter in the hypothalamus in rat model of post-stroke restraint stress.