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目的探讨复合B族维生素对高同型半胱氨酸血症(Hhcy)脑梗死患者神经功能预后的影响。方法选取2010年8月至2014年8月梅州市中医医院收治的180例Hhcy脑梗死患者作为研究对象,按随机数字表法将其分为观察组和对照组,各90例。对照组患者给予常规治疗,观察组患者在对照组基础上采用复合B族维生素进行治疗,比较两组患者治疗前后神经功能变化情况、血浆tHcy含量及日常生活能力。结果治疗6、12个月后,两组患者的NIHSS评分均明显低于治疗前,且治疗12个月后观察组患者的NIHSS评分明显低于对照组,差异均有统计学意义(均P<0.05);治疗3、6及12个月后,观察组患者的t Hcy含量均明显低于对照组,差异均有统计学意义(均P<0.05);治疗后,对照组和观察组患者的BI评分分别为(89±15)分、(88±13)分,均明显高于治疗前,差异有统计学意义(P<0.05),但组间比较差异无统计学意义(P>0.05)。结论复合B族维生素可明显改善Hhcy脑梗死患者神经功能缺损程度,降低其血浆tHcy含量。
Objective To investigate the effect of compound B vitamins on neurological outcome in patients with hyperhomocysteinemia (Hhcy) cerebral infarction. Methods A total of 180 patients with Hhcy cerebral infarction admitted from Meizhou TCM Hospital between August 2010 and August 2014 were enrolled in this study. They were divided into observation group and control group according to random number table method, and each group included 90 cases. The patients in the control group were given routine treatment. The patients in the observation group were treated with compound B vitamins on the basis of the control group. The changes of neurological function, plasma tHcy content and daily living ability were compared between the two groups before and after treatment. Results After 6 and 12 months of treatment, the NIHSS scores of the two groups were significantly lower than those before treatment, and the NIHSS scores of the observation group were significantly lower than those of the control group after 12 months of treatment (all P < 0.05). After 3, 6 and 12 months of treatment, the levels of t Hcy in the observation group were significantly lower than those in the control group (all P <0.05); after treatment, the levels of t Hcy in the observation group and the control group BI scores were (89 ± 15) and (88 ± 13) points respectively, which were significantly higher than those before treatment (P <0.05), but there was no significant difference between the two groups (P> 0.05) . Conclusion B complex vitamins can significantly improve the degree of neurological deficits in patients with Hhcy cerebral infarction and reduce the plasma tHcy content.