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膜联蛋白A7(Annexin A7)是一个Ca~(2+)依赖磷脂结合蛋白多基因家族的成员。既往研究表明Annexin A7亚细胞水平异常杂合性缺失与多种肿瘤的发生、发展、转移以及侵袭相关。Annexin A7在胶质母细胞瘤、黑色素瘤以及前列腺癌的发病过程中似乎起到肿瘤抑制作用;但是Annexin A7在肝癌、胃癌、鼻咽癌、结直肠癌和乳腺癌中似乎促进恶性肿瘤发展,但是其确切作用仍存在争议。文章将就Annexin A7与消化系统恶性肿瘤之间的关系及其作用机制进行总结和讨论,探讨其作为评价某些肿瘤的诊断、治疗和预后生物标志物的潜在价值。
Annexin A7 is a member of a multi-gene family of Ca2 + -dependent phospholipid-binding proteins. Previous studies have shown that the loss of abnormal heterozygosity at the subcellular level of Annexin A7 is associated with the occurrence, development, metastasis and invasion of various tumors. Annexin A7 appears to act as a tumor suppressor in the pathogenesis of glioblastoma, melanoma, and prostate cancer; however, Annexin A7 appears to promote malignant tumor development in liver, stomach, nasopharyngeal, colorectal and breast cancers, However, its exact role remains controversial. The article will summarize and discuss the relationship between Annexin A7 and digestive system malignancies and its mechanism of action, and discuss its potential value as a biomarker for the diagnosis, treatment and prognosis of some tumors.