论文部分内容阅读
目的:分析我国白塞病(Behcet’s disease,BD)人群的临床特点及不同性别BD患者间的临床差异。方法:收集复旦大学附属华东医院2013年10月至2015年10月住院确诊为BD的375例患者的临床资料,分析其临床表现、系统受累及不同性别间的临床表现差异。结果:375例BD患者的平均发病年龄为(38±13)岁,平均病程为(7.69±7.39)年。口腔溃疡是患者最常见的临床症状(98.9%),其后依次为外阴溃疡(64.5%)、结节性红斑(41.6%)及眼部受累(38.7%)。BD患者的首发症状中,口腔溃疡最常见(85.3%),其后依次为结节性红斑(5.3%)、眼炎(3.2%)、生殖器溃疡(2.1%)、胃肠道溃疡(1.9%)、关节炎/关节痛(1.9%)及发热(0.3%)。临床表现上,男性BD患者的眼部病变及毛囊样皮疹明显多于女性患者(P<0.001,P=0.001)。女性BD患者的外阴溃疡发生率明显多于男性(P=0.040),女性的血液系统受累亦明显多于男性(P=0.024)。BD患者的葡萄膜炎和肠溃疡一般不并存。女性BD患者红细胞沉降率、IgG及IgM升高比例明显多于男性,差异有统计学意义(P值分别为0.001、0.012、0.009)。结论 :BD患者的临床表现多种多样,可累及多个系统,且存在性别差异。
OBJECTIVE: To analyze the clinical characteristics of Behcet’s disease (BD) and the clinical differences among patients with BD in different gender. Methods: The clinical data of 375 patients diagnosed as BD from October 2013 to October 2015 in Huadong Hospital affiliated to Fudan University were collected. The clinical manifestations, systemic involvement and clinical manifestations among different sexes were analyzed. Results: The mean age at onset of 375 BD patients was (38 ± 13) years and the average duration was (7.69 ± 7.39) years. Oral ulcer is the most common clinical symptom in patients (98.9%), followed by vulvar ulcer (64.5%), erythema nodosum (41.6%) and ocular involvement (38.7%). Among the first symptoms of BD, oral ulcer was most common (85.3%) followed by erythema nodosum (5.3%), ophthalmia (3.2%), genital ulcer (2.1%), gastrointestinal ulcer ), Arthritis / joint pain (1.9%) and fever (0.3%). In clinical manifestations, ocular lesions and hair follicle-like rash in male BD patients were significantly more than those in female patients (P <0.001, P = 0.001). Female BD patients had significantly more vulvar ulcers than men (P = 0.040), and women had significantly more blood system involvement than men (P = .024). Uveitis and intestinal ulcers in patients with BD generally do not co-exist. Erythrocyte sedimentation rate, IgG and IgM in women with BD were significantly higher than those in men (P = 0.001,0.012,0.009 respectively). Conclusion: The clinical manifestations of BD patients are diverse and can involve multiple systems with gender differences.