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目的探讨雌激素对女性X综合征患者血管内皮功能的影响。方法采用随机、对照、单盲方法将 2 8例女性X综合征患者分为雌激素治疗组 (n =16 )和常规治疗组 (n =12 )。疗程均为 8周。治疗前后分别采用高分辨率血管超声检测肱动脉血流介导性舒张功能 (FMD)的变化和血中内皮素 1(ET 1)含量。结果雌激素组治疗后肱动脉FMD、ET 1较治疗前明显改善 ,与常规治疗组比较也有显著性差异 (P <0 .0 1)。结论雌激素可显著改善女性X综合征患者的血管内皮功能。
Objective To investigate the effect of estrogen on the endothelial function of female X syndrome. Methods Twenty-eight female X syndrome patients were divided into estrogen treatment group (n = 16) and conventional treatment group (n = 12) by randomized, controlled and single-blind method. The course of treatment is 8 weeks. Before and after treatment, the changes of brachial artery-mediated diastolic function (FMD) and the content of endothelin-1 (ET-1) in brachial artery were detected by high resolution ultrasound. Results The brachial artery FMD and ET 1 in the estrogen group were significantly improved after treatment compared with those in the conventional treatment group (P <0.01). Conclusion Estrogen can significantly improve the endothelial function of female X syndrome.