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本文报告了22例妊娠高血压综合症血浆中PGI_2和TxA_2的变化。发现在正常妊娠血浆中PGI_2是升高的,但在妊高症孕妇PGl_2则明显降低,且在轻、重妊高症之间PGI_2水平也有明显差异,重度妊高症低于轻度妊高症。而TxA_2变化与此相反,妊高症孕妇的TxA_2水平高于正常妊娠。重度又高于轻度妊高症。测定结果提示妊高症的发病机制可能与PGI_2合成减少和TxA_2生成过多可能有关。
This article reports the changes of plasma PGI_2 and TxA_2 in 22 patients with pregnancy-induced hypertension. PGI 2 was found to be elevated in normal pregnant women but significantly decreased in pregnant women with PIH, and PGI 2 levels were also significantly different between mild and severe pregnant women with severe PIH lower than those with mild PIH . In contrast, TxA_2 changed the level of TxA_2 in pregnant women with PIH compared with normal pregnancy. Severe and higher than mild pregnancy-induced hypertension. The results suggest that the pathogenesis of pregnancy-induced hypertension may be associated with reduced synthesis of PGI_2 and TxA_2 excessive production may be related.