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目的观察姑息性化疗在治疗晚期食管癌方面的临床疗效。方法选择我院2010年1月-2010年12月收治的37例晚期食管癌患者的临床资料,随机将患者分为观察组19例与对照组18例,对照组患者采用顺铂(DDP)单药化疗的方法,观察组患者在采用DDP的基础上,联合应用5-氟尿嘧啶(5-FU)。观察两组患者的临床疗效。结果经治疗后,观察组患者有效率高于对照组,观察组11例患者分别出现不同程度恶心、呕吐等副反应;对照组10例患者出现副反应;观察组患者1年生存15例,占比78.9%,2年生存11例,占比57.9%;观察组1年生存10例,占比55.6%,2年生存6例,占比33.3%。结论晚期食管癌的治疗是为有效延长患者生命,改善其生活质量,目前采用DDP联合应用5-FU是较为常用的治疗方案,相信随着更多抗癌药物的问世及应用,对姑息性治疗研究的进一步深入,新的用药组合会有效地降低毒性,延长患者的生命,提高生活质量。
Objective To observe the clinical effect of palliative chemotherapy in the treatment of advanced esophageal cancer. Methods The clinical data of 37 patients with advanced esophageal cancer who were admitted to our hospital from January 2010 to December 2010 were randomly divided into observation group (19 cases) and control group (18 cases). Patients in the control group were treated with cisplatin (DDP) Drug chemotherapy, the observation group of patients based on the use of DDP, combined with 5-fluorouracil (5-FU). To observe the clinical efficacy of two groups of patients. Results After treatment, the effective rate of the observation group was higher than that of the control group. In the observation group, 11 patients showed varying degrees of nausea and vomiting side effects respectively. In the control group, 10 patients had side effects. The 1-year survival rate of the observation group was 15 More than 78.9%, 2-year survival in 11 cases, accounting for 57.9%; observation group 1-year survival in 10 cases, accounting for 55.6%, 2-year survival in 6 cases, accounting for 33.3%. Conclusion The treatment of advanced esophageal cancer is to effectively prolong the life of patients and improve their quality of life. At present, the combination of DDP with 5-FU is a more commonly used treatment. It is believed that with the advent and application of more anti-cancer drugs, palliative treatment Further research, the new drug combination will effectively reduce the toxicity, prolong the life of patients and improve the quality of life.