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目的探讨间隔时间对口服小剂量硫酸亚铁治疗儿童缺铁性贫血(iron deficency anemia,IDA)疗效的影响。方法将148例IDA患儿随机分为每周组、隔日组和每日组,均分3次于餐后1h内口服小剂量硫酸亚铁,累计1mg/kg元素铁。持续观察5周,并在服药前后测定各项血液学指标,同时计算治愈率、有效率和总有效率。结果 3组患者的贫血状况均得到一定程度纠正,其中每日组疗效略高于隔日组,每周组疗效最低。结论小剂量口服硫酸亚铁对儿童IDA疗效肯定,考虑到隔日组不良影响较小且患者依从性高等特点,值得推荐。
Objective To investigate the effect of interval time on the efficacy of oral administration of low dose ferrous sulfate in children with iron deficiencyenary anemia (IDA). Methods 148 cases of IDA children were randomly divided into weekly group, every other day group and daily group, were divided into 3 times 1h postprandial oral small doses of ferrous sulfate, cumulative 1mg / kg elemental iron. Observed for 5 weeks, and measured before and after taking the hematological indicators, while calculating the cure rate, effective rate and total effective rate. Results The anemia in all three groups of patients was corrected to a certain extent. The daily effect was slightly higher than that in the second day, and the weekly effect was the lowest. Conclusion Small doses of oral administration of ferrous sulphate affirmed the efficacy of IDA in children. It is worth considering the small adverse effects of every other day and the high adherence of patients.