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目的探讨清胃活血汤联合法莫替丁治疗急性胃炎的疗效及安全性。方法选取急性胃炎患者70例,按照随机数字表法分为治疗组和对照组,各35例。对照组患者单纯给予静脉滴注法莫替丁治疗,治疗组患者在对照组基础上配合清胃活血方治疗。观察两组患者的中医证候积分、疗效和不良反应的发生情况。结果(1)治疗组总有效率为82.86%,明显高于对照组的60.00%(x2=0.034,P<0.05),差异具有统计学意义;(2)治疗前两组患者中医证候积分的差异无统计学意义(t=0.124,P>0.05),治疗后治疗组患者中医证候积分下降更加明显(t=-4.585,P<0.05),差异具有统计学意义;(3)治疗组患者不良反应发生率为11.43%,明显低于对照组的37.14%(x2=6.293,P<0.05),差异具有统计学意义。结论清胃活血汤联合法莫替丁治疗瘀血停滞型急性胃炎的疗效显著,不良发生发生率低,值得临床推广。
Objective To investigate the efficacy and safety of Qingwei Huoxue Decoction combined with famotidine in the treatment of acute gastritis. Methods Seventy patients with acute gastritis were selected and randomly divided into treatment group and control group according to the random number table. Patients in the control group were treated with intravenous famotidine only. Patients in the treatment group were treated with Qingwei Huoxue prescription on the basis of the control group. Observed two groups of patients with TCM syndrome score, efficacy and adverse reactions occurred. Results (1) The total effective rate of the treatment group was 82.86%, which was significantly higher than 60.00% (x2 = 0.034, P <0.05) of the control group, the difference was statistically significant; (2) There was no significant difference between the two groups (t = 0.124, P> 0.05). After treatment, the TCM syndrome score of the treatment group decreased more obviously (t = -4.585, P <0.05) Adverse reaction rate was 11.43%, significantly lower than the control group 37.14% (x2 = 6.293, P <0.05), the difference was statistically significant. Conclusion Qingweihuoxue Decoction combined with famotidine has obvious curative effect on stagnant acute gastritis with stagnant incidence and worthy of clinical promotion.