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目的 探讨结节性甲状腺肿伴淋巴细胞浸润病变的临床病理特点及其与桥本病的关系。方法 收集112 1例结节性甲状腺肿和5 5例甲状腺腺瘤临床病理资料,对其中83例伴有淋巴细胞浸润的病例,结合其甲状腺功能和术后随访状况进行综合分析。结果 结节性甲状腺肿合并淋巴细胞浸润病例的比例为7 4 % (83/112 1) ,多为中年女性,组织学特点是在结节性甲状腺肿的基础上存在不同程度淋巴细胞浸润和滤泡上皮萎缩及嗜酸性变,76 %病例有囊性变或瘢痕,6例(7% )甲状腺自身抗体滴度升高,19%病例出现术后甲状腺功能低下。5 5例腺瘤都无明显淋巴细胞浸润。结论伴有淋巴细胞浸润的结节性甲状腺肿病例在临床和组织学上与桥本病有一定的相似性,是一种与自身免疫有关的炎症性增生性病变,可能是部分桥本病的起始阶段
Objective To investigate the clinicopathological features of nodular goiter with lymphocytic infiltration and its relationship with Hashimoto’s disease. Methods Clinicopathological data of 112 cases of nodular goiter and 55 cases of thyroid adenoma were collected and 83 cases with lymphocytic infiltration were analyzed. The thyroid function and postoperative follow-up were analyzed comprehensively. Results The proportion of nodular goiter with lymphocytic infiltration was 74% (83/1121), mostly middle-aged women. The histological feature was that there were different degrees of lymphocyte infiltration on the basis of nodular goiter and Follicular epithelial atrophy and eosinophilic changes, cystic lesions or scarring in 76% of cases, 6 cases (7%) increased thyroid autoantibody titer, postoperative thyroid dysfunction in 19% of cases. 5 5 cases of adenoma no obvious lymphocytic infiltration. Conclusion The cases of nodular goiter with lymphocytic infiltration have certain clinical and histological similarities with Hashimoto’s disease, which is an autoimmune-related inflammatory proliferative disease that may be partially Hashimoto’s disease Initial stage