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目的:对安神宁口服液中五味子的血清药物化学进行研究。方法:建立安神宁口服液及灌胃给予安神宁口服液后大鼠血清的HPLC指纹色谱分析方法;分析比较安神宁口服液、五味子单味液以及给药后所得血清样品,鉴定灌胃给予安神宁口服液后大鼠血中五味子化学成分变化,确定来源生药及其代谢产物。结果:大鼠灌胃给予安神宁口服液后从血中发现了15个入血成分,其中有两成分为五味子中所含的原型成分。结论:血中移行成分及代谢产物将成为安神宁口服液的体内直接作用物质,其来源生药为安神宁口服液的主要药物,对其进行深入的研究,将有助于阐明安神宁口服液的有效成分及作用机制。
Objective: To study the serum medicinal chemistry of schisandra chinensis in Anshenning oral liquid. Methods: The HPLC fingerprint chromatogram of serum of Anshenning oral liquid and oral administration of Anshenning oral liquid was established. The AQG oral liquid, Schisandra chinensis liquid and the serum sample after administration were analyzed and compared. Ning oral solution of rat blood Schisandra chemical composition changes to determine the source of crude drugs and their metabolites. Results: Fifteen blood components were found from the blood after oral administration of Anshening oral solution, of which two were the prototype components contained in Schisandrins. CONCLUSION: The blood migration components and metabolites will become the direct acting substances of Anshening oral liquid in vivo, and the origin medicine is the main drug of Anshenning oral liquid, and in-depth study on them will help to elucidate the effects of Anshenning oral liquid Active ingredients and mechanism of action.