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目的探究孕妇尿氟含量与新生儿先天性心脏病的相关性。方法选取2014年1月~2016年1月本院收治的117例合并先天性心脏病的婴儿为观察组,并选取同期我院接收的117例无先天性心脏病的婴儿为对照组。回顾性分析234例婴儿及其母亲的临床资料,分析孕妇尿氟含量与新生儿先天性心脏病的相关性。结果两组孕妇的年龄和孕周比较差异无统计学意义(P>0.05)。观察组孕妇的尿氟含量显著高于对照组患者,差异具有统计学意义(P<0.05)。观察组117例先天性心脏病胎儿中6例胎儿为足月分娩,111例胎儿为引产。其中有79例为间隔缺损,占先天性心脏病大多数,其次为动脉干畸形,为57例。多因素Logistic分析结果显示,母亲高血糖、母亲尿氟含量高、母亲为家庭主厨、母亲孕前及孕期接触化学物质、有先天性心脏病家族史、母亲合并症多、孕早期服用抗生素为新生儿先天性心脏病发生的独立危险因素(P<0.05)。孕前食用乳制品是其保护因素。结论母亲高血糖、尿氟含量高、为家庭主厨、孕前及孕期接触化学物质、有先天性心脏病家族史、合并症多、孕早期服用抗生素为新生儿先天性心脏病发生的危险因素,孕前食用乳制品是其保护因素。
Objective To investigate the correlation between urine fluoride content and neonatal congenital heart disease in pregnant women. Methods A total of 117 infants with congenital heart disease admitted from January 2014 to January 2016 in our hospital were selected as the observation group and 117 infants without congenital heart disease received in our hospital were selected as the control group. The clinical data of 234 infants and their mothers were analyzed retrospectively to analyze the correlation between urinary fluoride levels and neonatal congenital heart disease in pregnant women. Results There was no significant difference in age and gestational age between the two groups of pregnant women (P> 0.05). The urinary fluoride content of pregnant women in the observation group was significantly higher than that of the control group, the difference was statistically significant (P <0.05). The observation group of 117 cases of congenital heart disease in 6 fetuses for full-term childbirth, 111 cases of fetus as induction of labor. Among them, 79 cases were septal defects, accounting for the majority of congenital heart disease, followed by arterial malformations, 57 cases. Multivariate Logistic analysis showed that mothers had high blood sugar, high urinary fluoride levels in their mothers, and their mothers were house chefs. Their mothers were exposed to chemicals before and during their pregnancy. Their families had a family history of congenital heart disease, maternal complications and antibiotics in their first trimester were newborn Children with congenital heart disease were independent risk factors (P <0.05). Pre-pregnancy dairy products are the protective factors. Conclusion The mothers with high blood sugar and urinary fluoride content are the risk factors for the birth of congenital heart disease in neonates due to the fact that the family chef is exposed to chemical substances before and during pregnancy, with a family history of congenital heart disease, multiple complications and early pregnancy antibiotics. Pre-pregnancy dairy products are the protective factors.