论文部分内容阅读
对我院近期耐环丙沙星阴性菌进行了相关因素分析；比较了亚胺培南等１１种抗菌药物对耐药菌的抗菌作用；对临床针对性治疗耐药菌感染提出了建议。结果表明：耐药菌主要为大肠杆菌和克雷伯氏菌。大部分病原菌在接触药物前已对环丙沙星产生耐药性。亚胺培南、第三代头孢菌素和氨曲南对耐药菌的抗菌作用明显较强。提示：遇到病原菌多数为大肠杆菌的泌尿道感染以及病原菌主要为克雷伯氏菌的革兰氏阴性菌肺炎时，不应再以此类药物作为经验性用药方案。严格控制氟喹诺酮类口服制剂在门诊患者中广泛使用是有效减少耐药菌的重要途径。亚胺培南、第三代头孢菌素和氨曲南均可作为针对性治疗耐药菌感染的方案或作为替换用药时的主要品种。
Ciprofloxacin-resistant ciprofloxacin-resistant bacteria in our hospital recently carried out the relevant factors analysis; compared eleven kinds of antibacterials such as imipenem antibacterial effect on drug-resistant bacteria; clinical recommendations for the treatment of drug-resistant bacterial infections. The results showed that the main drug-resistant bacteria were Escherichia coli and Klebsiella. Most pathogens are resistant to ciprofloxacin before they are exposed to the drug. The antibacterial effect of imipenem, third generation cephalosporins and aztreonam on drug-resistant bacteria was significantly stronger. Tip: Encounter the majority of pathogenic bacteria Escherichia coli urinary tract infections and Klebsiella pneumoniae pathogenic bacteria Klebsiella pneumonia, should no longer be used as an empirical drug regimen. Strict control of fluoroquinolones oral formulations widely used in outpatients is an effective way to reduce drug-resistant bacteria. Imipenem, the third generation of cephalosporins and aztreonam can be used as targeted treatment of drug-resistant bacterial infection programs or as the main drug replacement.