Prader—Willi 综合征是Prader 等在1953年首先报告的。其特征为在乳儿期患儿吮乳无力、肌张力低下、哭声微弱;而从幼儿期到学童期则出现多食、肥胖、身矮,特殊面貌、智力发育迟延、性腺发育迟缓、中枢神经功能异常。其中由于多食而致肥胖是最明显的症状。患儿为了满足旺盛的食欲往往偷吃、滥食不洁之物,甚至偷盗钱物米换食品。为了增加胃的膨满感以往曾有人使用葡甘露聚糖(glugomanan),内啡肽(β—endorphen)和吗啡拮抗剂纳洛酮(naloxone)等,但这些药物容易滥用成瘾,引起中枢性兴奋,在日本并未推广。马吲哚(mazindol)为Sandoz 出品,是一种非苯 Prader-Willi syndrome was first reported by Prader et al in 1953. It is characterized by weakness in suckling milk, weak muscle tone and cries of weakness in infants, while eating, obesity, body shortness, special appearance, mental retardation, gonadal retardation, central nervous system Abnormal function. Among them, obesity is the most obvious symptom due to eating more. Children in order to meet the strong appetite often steal, overuse unclean things, and even steal money for rice for food. Glugomanan, β-endorphin, and naloxone, a morphine antagonist, have been used in the past to increase the stomach’s fullness. However, these drugs are susceptible to addiction and cause centrality Excited, not promoted in Japan. Mazindol, a product of Sandoz, is a non-benzene