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目的了解平均红细胞体积(MCV)平均红细胞血红蛋白含量(MCH)下降的育龄人群地中海贫血基因携带情况,指导双方均携带同类型地贫基因的夫妇进行产前诊断.降低中间型和重型地贫胎儿出生率。方法对随机婚配的男女在接受婚前医学检查、孕前检查、产前检查时使用血细胞分析仪进行地贫筛查。判读标准为血常规MCV<82fl和MCH<27pg为地贫初筛阳性,初筛阳性做α、β地贫基因分析。结果 MCV MCH诊断地中海贫血敏感性为88.322%,MCV、MCH下降的育龄人群地贫基因携带率极高,双方均携带同类型地贫基因的夫妇应进行产前诊断,从而降低中间型和重型地贫胎儿出生率。结论 MCV MCH作为地中海贫血筛查方法简单、经济实用。
Objective To understand the prevalence of thalassemia carriers in reproductive age population with mean red blood cell mass (MCH) decreased in the mean corpuscular volume (MCV) and to guide the couples who carry the same type of thalassemia gene to carry out prenatal diagnosis.Improve the birth rate of intermediate and severe thalassemia . Methods Male and female with random marriage were subjected to thalassemia screening with pre-marital medical examination, pre-pregnancy examination and prenatal examination using hematology analyzer. Interpretation criteria for the blood of MCV <82fl and MCH <27pg positive for thalassemia screening, positive screening for α, β thalassemia gene analysis. Results The sensitivity of MCV MCH for diagnosing thalassemia was 88.322%. The carrier rate of thalassemia was very high in those of childbearing age with MCV and MCH. Both couples carrying the same type of thalassemia gene should be diagnosed prenatal to reduce the incidence of intermediate and heavy land Poor birth rate. Conclusion MCV MCH as a thalassemia screening method is simple, economical and practical.