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许多血吸虫病流行国家已大规模地用吡喹酮化疗。因此不仅需要了解化疗对排卵量的影响,而且需了解其对宿主肝脏病变的作用。作者于1989年设计了儿童门脉周围纤维化(periportal fibrosis,PF)的超声波检查分级方法。本文运用该方法观察了吡喹酮治疗七个月后患儿的肝脾纤维病变。方法:选择苏丹Gezira灌溉区536名感染曼氏血吸虫的在校儿童。随机分成两组,分别接受20mg/kg或40mg/kg吡喹酮治疗。七个月后,对其中420名儿童进行随访
Many schistosomiasis endemic countries have been using praziquantel for chemotherapy on a large scale. Therefore, not only need to understand the impact of chemotherapy on ovulation, but also need to understand its role in the host liver lesions. In 1989, the authors designed an ultrasonographic procedure for the classification of children’s periportal fibrosis (PF). This method was used to observe the changes of hepatic and splenic fibrosis in children after praziquantel treatment for seven months. METHODS: 536 children infected with Schistosoma mansoni were selected for the Gezira Irrigation Area in Sudan. Randomly divided into two groups, respectively, received 20mg / kg or 40mg / kg praziquantel treatment. Seven months later, 420 children were followed up