恶性肿瘤的侵袭转移是引起肿瘤患者治疗失败和死亡的主要原因之一。肿瘤的侵袭与转移机制复杂,是一个多环节、多步骤的过程,其中肿瘤合成分泌大量的胞外蛋白水解酶,穿透细胞外基质尤为重要,该环节可分为粘附、水解、游走三个步骤,而基质蛋白酶水解作为其中的关键倍受人们的关注 Invasion and metastasis of malignant tumors is one of the main causes of tumor failure and death in cancer patients. Tumor invasion and metastasis mechanism is complex, is a multi-link, multi-step process, in which tumor synthesis and secretion of large amounts of extracellular proteolytic enzymes, penetrate the extracellular matrix is ​​particularly important, the link can be divided into adhesion, hydrolysis, walk Three steps, and matrix protease hydrolysis as one of the key much people’s attention