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目的：研究头孢噻肟（ｃｅｆｏｔａｘｉｍｅ，ＣＴＸ）在５０ｇ·Ｌ－１葡萄糖输液中与维生素Ｂ６等６种注射剂配伍的稳定性，为临床合理用药提供科学依据。方法：选择２５，３７℃在５ｈ内观察配伍液的外观、ｐＨ及ＣＴＸ紫外光谱的变化，用紫外分光光度法测定ＣＴＸ的含量。结果：其稳定性与温度和ｐＨ有关。结论：在２５℃，与６种注射剂配伍５ｈ内都稳定可用；在３７℃，与维生素Ｃ、氨茶碱注射剂配伍，则最好在３ｈ内用完。
OBJECTIVE: To study the stability of cefotaxime (CTX) in compatibility with six kinds of injections such as vitamin B6 in 50g · L-1 glucose infusion and to provide a scientific basis for clinical rational drug use. Methods: The appearance, pH and the changes of CTX UV spectra were observed at 25 and 37 ℃ in 5h. The content of CTX was determined by UV spectrophotometry. Results: The stability is related to temperature and pH. Conclusion: It is stable and can be used within 5 hours when it is compatible with 6 kinds of injection at 25 ℃. When it is compatible with vitamin C and aminophylline injection at 37 ℃, it is best to use it within 3 hours.