论文部分内容阅读
目的探讨伴有轻、中度肾功能不全的慢性肾小球肾炎 (chronic glomerulonphritis,CGN)患者 ,是否存在胰岛素抵抗 (IR) ,以及苯那普利对胰岛素抵抗的影响。方法采用口服葡萄糖耐量试验 ,测定 38例 CGN患者和 1 5例正常人空腹及糖负荷后血糖、血胰岛素水平和胰岛素敏感指数 (ISI)。观察 CGN患者服用苯那普利 3个月后 ISI变化。结果 CGN患者 ISI显著低于对照组 (P<0 .0 1 ) ,服用苯那普利后 CGN患者 ISI显著升高 (P<0 .0 5 )。结论 CGN患者存在胰岛素抵抗 ,苯那普利具有改善胰岛素抵抗的作用
Objective To investigate the presence or absence of insulin resistance (IR) in patients with chronic glomerulonephritis (CGN) accompanied by mild and moderate renal insufficiency and the effect of benazepril on insulin resistance. Methods The oral glucose tolerance test was used to determine the fasting blood glucose, blood glucose, insulin sensitivity index (ISI) in 38 CGN patients and 15 normal subjects. Changes in ISI after 3 months in benazepril CGN patients were observed. Results The ISI of CGN patients was significantly lower than that of the control group (P <0.01). The ISI of CGN patients after benazepril treatment was significantly higher (P <0.05). Conclusion CGN patients have insulin resistance, and benazepril has the effect of improving insulin resistance