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[目的 ]探讨乳母口服维生素K1 预防婴儿维生素K缺乏出血症 (VKDB)的效果。 [方法 ]干预组 9871名乳母自分娩后每 1 0天口服维生素K1 片 1 0mg直到满 3个月 ,未干预组 1 0 0 1 0人不服 ,均观察婴儿 6个月内的出血情况 ;同时小样本采集乳母初乳、1月乳、2月乳汁和婴儿的脐血、1个月、2个月静脉血分别测定维生素K1 和维生素K缺乏诱导蛋白 (PIVKA Ⅱ )含量。 [结果 ]干预组发生 1例VKDB ,未干预组发生 2 2例VKDB ;干预组母亲 1个月乳汁和 2个月乳汁中维生素K1 含量分别是未干预组的 3 5倍和 3倍 ,干预组婴儿 1个月外周血PIVKA Ⅱ阳性率和未干预组比较未表现出统计学差异。 [结论 ]母亲口服维生素K1 可明显提高母乳维生素K1 的含量 ,有效减少母乳喂养儿VKDB的发生
[Objective] To investigate the effect of maternal oral vitamin K1 in preventing infantile vitamin K deficiency (VKDB). [Method] A total of 9,871 lactating nurses in the intervention group were given oral vitamin K1 10 mg every 10 days until their full 3 months after delivery, while those in the non-intervention group were dissatisfied with 1 0 0 1 0, and the bleeding within 6 months was observed. Meanwhile, A small sample collection Colostrum, milk in January, February breast milk and infant cord blood, 1 month, 2 months of venous blood were measured vitamin K1 and vitamin K deficiency induced protein (PIVKA Ⅱ) content. [Results] There was 1 case of VKDB in the intervention group and 22 cases of VKDB in the non-intervention group. The content of vitamin K1 in the milk of 1 month and 2 months in the intervention group was 35 times and 3 times that of the non-intervention group, There was no significant difference in the positive rate of PIVKA Ⅱ in infants one month after treatment compared with the non-intervention group. [Conclusion] Mother’s oral administration of vitamin K1 can significantly increase the content of vitamin K1 in breast milk and effectively reduce the occurrence of VKDB in breast-fed infants