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难治性原发性血小板减少性紫癜(refractory idiopathic thrombocytopenic purpura,RITP)是指用皮质激素、肝切除、免疫抑制剂经适当剂量和治疗时间仍无效的原发性血小板减少性紫癜。近年来已有多种新的治疗方法,多数是通过免疫机制达到治疗效果,各有一定疗效,现介绍如下: 1 达那唑(dnnazol,DNZ) 达那唑是人工合成的17烷基雄激素,其性刺激极轻微。达那唑的剂量一般为400～800mg/d,治疗时间至少2月,治疗开始后中数时间2.7±3月开始见效。如短于6个月,复发较多见,Majerj用DNZ治疗18例RITP。方法:DNZ200mg每天2次,连服3个月,结果5例完全缓解,随后以小剂量维持,随访一年未复发,6例部分缓解,2例在小剂量长期治疗中出现较好的反应,7例无效。国内吕世藩治疗12例RITP,10例均有不同
Refractory idiopathic thrombocytopenic purpura (RITP) refers to primary thrombocytopenic purpura that is still ineffective with corticosteroids, hepatectomy, immunosuppressants at the appropriate dose and duration of treatment. In recent years, there are a variety of new treatments, most of which are achieved through the immune mechanism of treatment, each have a certain effect, are as follows: 1 danazol (dnnazol, DNZ) danazol is a synthetic 17 alkyl androgen, Its sexual stimulation is minimal. The dose of danazol is generally 400 ~ 800mg / d, the treatment time of at least 2 months after the start of treatment median time 2.7 ± 3 months effective. If less than 6 months, recurrence is more common, Majerj with DNZ treatment of 18 cases of RITP. Methods: DNZ200mg twice a day, and even for 3 months, the results of 5 cases of complete remission, followed by a small dose to maintain a follow-up one year did not relapse, 6 cases of partial remission, 2 cases of small doses of long-term treatment appeared better response, 7 cases invalid. Lv Shifan domestic treatment of 12 cases of RITP, 10 cases are different