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用家兔制成闭袢型、肠系膜静脉阻塞型及肠系膜动脉阻塞型的急性绞窄性肠梗阻模型,并以单纯性肠梗阻组和假手术组为对照。制模后1、4小时从兔耳静脉注射显像剂99m锝焦磷酸盐,用单光子发射计算机断层(SPECT)进行腹部平面显像的动态观察,并测定感兴趣区的摄取比值。结果显示:在闭袢型和肠系膜静脉阻塞型于注射显像剂后,绞窄肠段所在腹侧出现放射性浓聚,显像部位感兴趣区摄取比值明显大于单纯性肠梗阻组和假手术对照组;肠系膜动脉阻塞型上述改变不明显。本实验结果提示:闭袢型和静脉阻塞型绞窄缺血肠段早期有显像剂的聚集;SPECT的核素显像技术可作为早期诊断闭袢型和肠系膜静脉阻塞型肠梗阻有价值的辅助手段。
A rabbit model of acute strangulated intestinal obstruction with closed obturator mesenteric vein occlusion and mesenteric artery occlusion was established. Rabbits with simple intestinal obstruction and sham operation served as controls. 99m Tc-pyrophosphate was injected into the rabbit ear veins 1 and 4 hours after the model establishment. Dynamic imaging of the abdomen was performed by single photon emission computed tomography (SPECT), and the uptake of the region of interest was determined. The results showed that in the obstructive and mesenteric vein occlusion type injection imaging agent, the radioactive enrichment appeared in the ventral part of strangulated intestinal segment, and the imaging area of interest area was significantly larger than that of simple intestinal obstruction group and sham operation control group Group; mesenteric artery obstruction of the above change is not obvious. The results of this study suggest that there is an aggregation of imaging agents in the closed intestine and venous occlusive early ischemic segments of the intestine, and SPECT imaging may be valuable in the early diagnosis of obstructive and mesenteric occlusive intestinal obstruction Auxiliary means.