论文部分内容阅读
Ｗｉｓｔａｒ系自发性脑积水大鼠，大体解剖可见动物颅骨膨隆如球形，骨质变薄，小血管增多，扩张。脑室腔高度扩张成橄榄形，脑实质菲薄。光镜下，各年龄组动物内脏未见显著改变，可见颅骨骨化不良、变形，侧脑室扩张，中央导水管某些区段有粘连、狭窄、阻塞和闭合，各脑室脉络膜丛则未见异常。该病见于初生仔鼠，多在生后２４ｈ内即可由于头部轻微隆起，覆盖于脑壳的皮肤紧张而被发现，症状随患鼠生长发育逐渐明显或加重。病理学检查，主要表现为脑的器质性病变，从病变不伴炎症反应，以及本病发生无流行蔓延趋势及无明显外因诱发等综合考虑，初步排除传染性致病的可能性。病理学检查未见脑室脉络膜丛的增生情况，提示本病不是由于脑脊液牛成过多所致，从中脑导水管部分区段的粘连、狭窄、阻塞、闭合等来看，本病发生可能是由于脑脊液循环障碍，致脑室积液过多，颅压增高，致使颅腔、脑室腔高度扩张，颅骨骨化不良、变形、前后卤门闭合差，大脑实质也因受压而发育不良，菲薄
Wistar Department of spontaneous hydrocephalus rats, gross anatomy of the skull bulge can be seen as spherical, thinning of the bone, small blood vessels increase, expansion. High ventricular cavity expansion into olive-shaped, thin brain parenchyma. Under light microscope, there was no significant change in viscera of animal in all age groups. The skull had poor ossification, deformation, dilatation of lateral ventricle, adhesion, stenosis, occlusion and occlusion in some sections of central aqueduct and no abnormalities . The disease seen in newborn pupils, mostly within 24 hours after birth can be slightly raised due to the head, covering the skin of the skull and was found to be nervous, with the development of symptoms of rats gradually obvious or worse. Pathological examination, the main manifestations of organic brain lesions, lesions from the inflammatory response, and the occurrence of the disease-free spread of the trend and no obvious external causes induced comprehensive consideration, the initial rule out the possibility of infectious disease. No pathological examination of ventricular choriocarcinoma hyperplasia, suggesting that the disease is not due to excessive cerebrospinal fluid due to the midbrain aqueduct section adhesion, stenosis, obstruction, closure, etc., the occurrence of this disease may be due to Circulation of cerebrospinal fluid disorders, resulting in excessive ventricular effusion, increased intracranial pressure, resulting in a high degree of expansion of the cranial cavity, ventricular cavity, skull dysplasia, deformation, before and after the closure of the halo door, due to compression of the brain parenchyma and poor, meager