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1988年Huang等报道,给24例(年龄5～69岁,男13例,女11例)急性早幼粒细胞性白血症(APL)患者试行投予全反视黄酸(All-trans retinoic acid,A-tRA),45～100mg/m~2/日,发现全部病例的骨髓增生低下像获得完全缓解。副作用仅为口唇及皮肤粘膜干燥、头痛和消化道症状。与历来的细胞毒性化学疗法不同,当投予A-tRA时,可见病态细胞趋向细胞成熟,成为本疗法的形态学分化特征。
In 1988 Huang et al reported that 24 patients (5 to 69 years old, 13 males and 11 females) with acute promyelocytic leukemia (APL) were administered with all-trans retinoic acid , A-tRA) 45 ~ 100mg / m ~ 2 / day, found in all cases of bone marrow hyperplasia was completely relieved. Side effects are only dry lips and skin mucous membranes, headache and gastrointestinal symptoms. Unlike conventional cytotoxic chemotherapy, when A-tRA is administered, it is seen that pathological cells tend to mature into cells and become morphologically differentiated characteristics of the present therapy.