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目的 评价1 8F 脱氧葡萄糖 (FDG)双探头符合线路断层显像 (DHTC)对非小细胞肺癌(NSCLC)患者淋巴结转移及其分期的可行性 ,并与CT结果进行对比。方法 15 9例确诊为NSCLC患者均在 2周内完成FDGDHTC和CT检查 ,1个月内完成外科手术后进行病理检查或纵隔镜、穿刺活组织检查等 ,以判断有无淋巴结转移。FDGDHTC和CT检查结果均与最终病理检查结果比较。结果15 9例NSCLC患者中 10 3例有淋巴结转移。FDGDHTC检查的灵敏度、特异性和准确性 (分别为 91% ,98%和 94% )均较CT(分别为 82 % ,6 4%和 75 % )高。在淋巴结转移的分期评估中 ,FDGDHTC低估 10例 (6 % ) ,仅 1例 (0 6 % )高估 ;而CT则高估 2 3例 (14% ) ,低估 2 1例 (13% )。结论 FDGDHTC用于NSCLC患者纵隔淋巴结转移及其分期是一可靠的非创伤性方法。
Objective To evaluate the feasibility of 18F-FDG dual-head coincidence tomography (DHTC) for lymph node metastasis and staging in patients with non-small cell lung cancer (NSCLC) and to compare with CT results. Methods Fifteen patients diagnosed as NSCLC completed FDGDHTC and CT examination within two weeks. One month after surgery, pathological examination or mediastinoscopy and biopsy were performed to determine whether there was lymph node metastasis. FDGDHTC and CT examination results were compared with the final pathological examination results. Results Of 15 9 NSCLC patients, 103 had lymph node metastases. The sensitivity, specificity, and accuracy of FDGDHTC were 91%, 98%, and 94% higher than those of CT (82%, 64%, and 75%, respectively). FDGDHTC was underestimated in 10 patients (6%) and only 1 patient (0 6%) in staging assessment of lymph node metastasis, while CT was overestimated in 23 patients (14%) and underestimated in 21 patients (13%). Conclusion FDGDHTC is a reliable and non-invasive method for mediastinal lymph node metastasis and staging in patients with NSCLC.