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FLT3受体是Ⅲ型受体酪氨酸激酶家族中成员。FLT3突变是急性髓细胞白血病(AML)中一种最常见基因改变,1/3的AML患者有该基因突变,最主要的突变包括FLT3近膜区(JM)内部串联重复突变(ITD)和“活化环”处点突变(TKD)。这些突变导致FLT3下游信号通路持续活化和变异细胞增殖[1]。本
The FLT3 receptor is a member of the type III receptor tyrosine kinase family. FLT3 mutation is one of the most common genetic alterations in acute myeloid leukemia (AML). One out of three AML patients have this gene mutation. The most common mutations include the ITT in the FLT3 proximal membrane region (JM) “Activated ring ” point mutation (TKD). These mutations lead to sustained activation of FLT3 downstream signaling pathway and mutant cell proliferation [1]. this